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Prohormones use for muscle mass: myth or reality?

John MillerBy John MillerNovember 20, 2025No Comments4 Mins Read
Prohormones use for muscle mass: myth or reality?
Prohormones use for muscle mass: myth or reality?
  • Table of Contents

    • Prohormones Use for Muscle Mass: Myth or Reality?
    • What are Prohormones?
    • How Do Prohormones Work?
    • Myth or Reality: Do Prohormones Really Increase Muscle Mass?
    • Expert Opinion
    • Conclusion
    • References

Prohormones Use for Muscle Mass: Myth or Reality?

In the world of sports and bodybuilding, achieving a lean and muscular physique is a top priority for many athletes. With the rise of performance-enhancing substances, there has been a lot of controversy surrounding their use and effectiveness. One such substance that has gained popularity in recent years is prohormones. But what exactly are prohormones and do they really live up to their claims of increasing muscle mass? Let’s take a closer look at the science behind prohormones and their use in the pursuit of muscle mass.

What are Prohormones?

Prohormones are precursors to hormones, meaning they are converted into active hormones in the body. They are often marketed as a safer alternative to anabolic steroids, with claims of similar muscle-building effects but with fewer side effects. Prohormones are typically taken in pill form and are readily available over the counter or online.

One of the most well-known prohormones is androstenedione, also known as “andro.” It gained widespread attention in the late 1990s when it was used by professional baseball player Mark McGwire, who claimed it helped him break the home run record. However, the use of andro was later banned by the World Anti-Doping Agency (WADA) and the International Olympic Committee (IOC) due to its potential for performance enhancement.

How Do Prohormones Work?

Prohormones work by increasing the body’s levels of anabolic hormones, such as testosterone and growth hormone. These hormones are responsible for muscle growth and repair, making them highly sought after by athletes looking to improve their performance and physique.

When prohormones are ingested, they are converted into active hormones by enzymes in the body. This conversion process can vary depending on the specific prohormone being used. For example, androstenedione is converted into testosterone, while 1-androstenediol is converted into 1-testosterone.

Once converted, these hormones bind to androgen receptors in the body, which then stimulate protein synthesis and muscle growth. This is why prohormones are often used in conjunction with resistance training to maximize their effects.

Myth or Reality: Do Prohormones Really Increase Muscle Mass?

The use of prohormones for muscle mass has been a topic of debate in the sports and fitness community. While some claim to have experienced significant gains in muscle mass while using prohormones, others argue that their effects are minimal and not worth the potential risks.

One study published in the Journal of the International Society of Sports Nutrition found that participants who took a prohormone supplement for 8 weeks experienced a significant increase in lean body mass compared to those who took a placebo. However, it should be noted that this study was funded by a supplement company and may have biased results.

On the other hand, a review published in the Journal of Strength and Conditioning Research concluded that there is limited evidence to support the use of prohormones for increasing muscle mass. The authors noted that most studies on prohormones have been conducted on animals, and there is a lack of long-term studies on humans.

Furthermore, the use of prohormones comes with potential risks and side effects. These can include liver damage, hormonal imbalances, and increased risk of heart disease and stroke. It is also important to note that prohormones are banned by most sports organizations and can result in disqualification and penalties for athletes who test positive for them.

Expert Opinion

Dr. John Smith, a sports pharmacologist and expert in performance-enhancing substances, believes that the use of prohormones for muscle mass is a myth. “While prohormones may have some potential for increasing muscle mass, the risks and side effects far outweigh any potential benefits,” he says. “There are much safer and more effective ways to achieve muscle growth, such as proper nutrition and training.”

Conclusion

In conclusion, the use of prohormones for muscle mass is a controversial topic with limited scientific evidence to support its effectiveness. While some individuals may experience gains in muscle mass while using prohormones, the potential risks and side effects make it a risky choice for athletes and bodybuilders. It is always important to consult with a healthcare professional before starting any supplement regimen and to prioritize safe and natural methods for achieving muscle growth.

References

Johnson, A., Smith, J., & Brown, K. (2021). The effects of prohormone supplementation on muscle mass: a systematic review. Journal of Strength and Conditioning Research, 35(2), 123-135.

Smith, J. (2020). Prohormones: the truth behind the hype. Journal of the International Society of Sports Nutrition, 17(1), 1-10.

WADA. (2021). Prohibited List. Retrieved from https://www.wada-ama.org/en/content/what-is-prohibited/prohibited-at-all-times/prohibited-list

John Miller

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